The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research - PubMed
Treatment-resistant schizophrenia (TRS), the persistence of positive symptoms despite ≥2 trials of adequate dose and duration of antipsychotic medication with documented adherence, is a serious clinical problem with heterogeneous presentations. TRS can vary in its onset (at the first episode of psyc …
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