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04 February 2025

Evolving Avian Influenza Threat Raises Alarm Among Health Officials

Recent outbreaks of H5N1 and H5N9 strains highlight the growing potential for mutations and heightened risks to public health.

Avian influenza is once again making headlines as new outbreaks are reported, raising concerns about the virus's potential to evolve and affect human health. The emergence of various strains, particularly H5N1 and the newly identified H5N9, compels public health officials to remain vigilant.

At the start of January 2024, the United States reported its first death from H5N1, marking a significant event amid widespread concern. The US Department of Agriculture (USDA) confirmed 81 detections of highly pathogenic avian flu across 24 states from late December to mid-January, affecting commercial poultry operations and wild birds alike.

Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota, noted the alarming number of poultry operations affected: “If you look at what’s happened the last eight weeks, the number of poultry operations... is absolutely stunning,” he told Axios. This outbreak isn’t just devastating for farmers; it threatens to exacerbate existing egg supply shortages, driving prices up.

The situation is particularly dire as wild waterfowl, often asymptomatic carriers of the virus, comeling with domestic flocks. The changing migration patterns have allowed certain species to overwinter, compounding the risks as they spread the virus to poultry operations. States like Pennsylvania and New York have already culled thousands of birds to contain spread.

Ed Hutchinson, Senior Lecturer at the MRC-University of Glasgow Centre for Virus Research, emphasized the difficulty of transmission to humans underlining virus adaptability to host species. “Because viruses are closely adapted to specific host species, it’s really hard for bird flu to infect humans...,” Hutchinson stated. This relative rarity does not diminish the alarming nature of the virus's mutations and potential for reassortment.

The recent discovery of the H5N9 strain at a duck farm in California adds complexity to the situation. This strain, mixing genetic material from several types of avian flu viruses, does not appear to pose a greater immediate threat to humans than H5N1. Nevertheless, experts like Richard Webby from the World Health Organization warn of the dangers if strains were to reassort with seasonal human influenza viruses.

While the public's attention is sharply focused on health concerns, the response from federal agencies has been muted, partly due to political dynamics affecting leadership transitions. Reports noted delays on communications from health agencies via scientific publications, raising alarms among health experts. “This idea ... is unprecedented,” Anne Schuchat, former principal deputy director at the CDC, remarked about the lack of communication surrounding public health issues.

Despite the challenges posed by avian influenza, scientists are engaged in developing vaccines and medications to mitigate its spread. Moderna leads efforts with significant government funding for its mRNA-based vaccines aimed at both avian and pandemic influenza viruses. The hope is to bolster defenses against future outbreaks as historical precedents, like SARS and the COVID-19 pandemics, remind us just how quickly health crises can escalate.

Dr. Seema Lakdawala, from Emory University, posited, “What’s shocking to me is we’re letting nature do this experiment,” as she highlighted the potential for the virus to gain mutations necessary for airborne transmission. This potential for H5N1 to adapt and become human-transmissible cannot be ignored.

With over 950 dairy herds affected and 19 million birds lost to this avian flu crisis, the agricultural impact is immense. Customers are already feeling the repercussions as egg prices reached upwards of $8 per dozen, with 240,000 birds affected at recent site outbreaks.

The combination of scientific research and public health readiness will be key to managing the avian influenza threat. The lessons learned from previous pandemics stress the importance of coordinated responses and transparent communication among health authorities as we navigate this complex and potentially hazardous situation.

Overall, the fusion of new strains and human interfaces with animals necessitates renewed efforts for tracking, testing, and readiness against infectious diseases. It’s not just farmers at risk; it's the global population who may inadvertently face the brunt of this looming threat. With the stakes this high, the call for preparedness and proactive action has never been more pressing.