The increasing use of multiwalled carbon nanotubes (MWCNT-NP) across various industries has raised significant health concerns, particularly relating to their potential toxicity. A recent study conducted on Swiss albino mice provides substantial insights, indicating detrimental impacts on enzymatic activities and histopathological variations following MWCNT exposure.
The study aimed to evaluate the biohazards associated with MWCNT-NP exposure by analyzing serum enzymatic activities and tissue alterations. Swiss albino male mice were separated and subjected to oral administration of MWCNT-NP at two different doses — 0.45 µg and 0.90 µg — for periods of seven or fourteen days. A control group was established, and after the exposure duration, various blood samples and tissue examinations were conducted.
Results revealed significant increases (p < 0.05) in key enzymes, including Angiotensin Converting Enzymes (ACE), Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), and Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidase enzyme. The exposed groups exhibited notable histopathological damage across target organs like the liver, lungs, and testes, potentially undermining their functionality.
The findings are particularly alarming, as elevated ACE levels were linked to disturbances impacting male fertility. Specifically, histopathological evaluations revealed severe degeneration of seminiferous tubules and hyperplasia of Leydig cells among mice subjected to MWCNTs for fourteen days. This correlation signifies intense oxidative stress and associated cellular damage, which can reshape reproductive health outcomes.
Weighing the consequences of MWCNT exposure, the study emphasizes the necessity of stringent safety protocols for industrial practices. Researchers highlighted, "These findings underscored the significance of monitoring MWCNT-NP exposure, especially among workers involved in industries utilizing such materials.” Such statements resonate with the growing caution advocates aim to promote within occupational health discussions.
Tissue samples processed for histopathological analysis revealed advanced structural damage directly attributable to MWCNT exposure. Notable changes were observed through Hematoxylin and Eosin (H&E) staining methods, enabling visualization and documentation of inflammatory responses indicating elevated toxicity levels correlatively.
Taking these results under consideration, the research furthers existing knowledge on the need for rigorous risk assessments surrounding the use of MWCNTs. The documented connections between prolonged exposures and significant enzymatic disruptions create compelling urges for enhancing protective regulatory frameworks to safeguard workers against potential health hazards posed by these nanoparticles.
Conclusively, this investigation stresses the exigency of addressing MWCNT-NP effects, pushing for improved dissemination of safety measures within industrial applications. Future studies are pivotal to ascertain the full extent of MWCNT toxicity, facilitating informed strategies for managing worker exposure.