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Science
13 March 2025

Revolutionary Ionic Actuators Enhance Medical Device Efficiency

New polyrotaxane interface offers unprecedented ionic transport for injectable actuators.

A groundbreaking development in the field of ionic actuators has been reported by researchers from Soochow University, showcasing the potential of polyrotaxane interfaces to significantly improve the efficiency of these devices. Ionic actuators are integral components within modern medical instruments and artificial intelligence systems as they convert electrical energy to mechanical movements. The study, published on March 12, 2025, reveals how these actuators achieve unique capabilities by taking advantage of the sliding-ring effect to control ion transport, enhancing their electro-mechanical transduction efficiency.

Current challenges faced by ionic actuators revolve around their limited energy transduction efficiency, primarily due to inadequate ion transport at their interfaces. This new research emphasizes overcoming these challenges, demonstrating electro-mechanical efficiencies reaching as high as 7.68%, which surpasses most existing materials and devices within this class. The actuators produced through polyrotaxane interfaces show energy densities of 38.8 kJ/m³, significantly higher than the energy density of mammalian skeletal muscle, around 8.0 kJ/m³. Such findings not only contribute to advancements in actuator technology but also enable the development of more effective and responsive medical devices.

The innovative nature of the polyrotaxane interface lies within its unique molecular structure. Researchers utilized α-cyclodextrin (α-CD) rings threaded onto polyethylene glycol (PEG) chains known for their high mechanical strength and flexibility. This setup allows the actuators to exhibit dynamic control of ion flow, facilitating faster ion migrations during actuation. The ability to adjust the ion channels by applying mechanical strains, as outlined by the researchers, ensures rapid and efficient response times during operation.

Experiments highlighted the potential applications of these actuators, particularly focusing on their ability to be directly injected for use within biological tissues with thicknesses of just 0.8 mm. This feature is particularly relevant for surgical navigation and physiological monitoring, where adaptability and precision are of the utmost importance. The authors of the study asserted, "The powerful actuator can easily push a plastic bottle with a weight 40 times higher than itself," emphasizing the practical applicability of these devices.

This breakthrough could lead to transformative changes within the medical field, making it possible for soft robotic devices to navigate complex biological environments, delivering drugs or assisting with surgical procedures seamlessly. The developed fiber-shaped actuators hold unique promise not just for navigational purposes, but for broader uses within drug delivery systems and other medical devices requiring low-voltage operations.

Evaluations conducted as part of the study showed these ionic actuators maintain performance stability with negligible degradation even after 100,000 repetitive cycles, validating their durability and reliability. This stability is complimented by the biocompatibility of the actuators, with live/dead assays demonstrating no cytotoxic effects when tested with WS-1 human fibroblasts, reinforcing the safety of the devices for potential medical use.

Overall, the introduction of these polyrotaxane-based ionic actuators not only outlines advancements within actuator technology but opens avenues for new applications, particularly within the field of minimally invasive medical procedures. The sliding-ring effect introduces innovative methodologies for enhancing ionic transport, thereby improving efficiency and performance standards. Researchers foresee future developments positioning these actuators as fundamental components within the next generation of smart material applications, invigorated by the growing demand for adaptable and efficient biomedical devices.