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Science
13 December 2024

Revisiting The Interbreeding Timeline Of Neanderthals And Humans

New studies reveal clearer insights on when and how Neanderthals mixed with ancient humans, reshaping our evolutionary story.

Recent breakthroughs have offered new insights about the timeline of interbreeding between Neanderthals and early modern humans, reshaping our narrative of ancient human history. Two separate studies have pinpointed this intermingling to around 50,500 years ago, extending to roughly 43,500 years ago, with evidence showing these interbreeding events may have occurred over approximately 7,000 years.

The significance of these findings cannot be overstated. Nearly everyone of non-African ancestry possesses about 1-2% of Neanderthal DNA, testifying to long-forgotten interactions between these distinct groups. But until now, the specifics, including duration and timing of these encounters, were murky. The recent research provides much-needed clarity.

According to one of the pivotal studies published in Nature, researchers examined the genomes of early European populations, particularly samples taken from modern humans dating back roughly 45,000 years from what is now Germany and the Czech Republic. This genomic analysis suggested interbreeding occurred not merely as sporadic events but as part of prolonged interactions, resulting from migrating populations overlapping spatially over thousands of years.

On parallel lines, another team, contributing to research published in Science, sifted through both ancient genomes and modern counterparts. Their work brought forward the idea of estimating this gene flow which occurred between 50,500 and 43,500 years ago. This collective analysis of 58 ancient genomes and current human data highlighted the deep-rooted genetic connections forged during this period.

Priya Moorjani, co-author and assistant professor of molecular and cell biology at UC Berkeley, emphasized the implication of these timelines, stating, “The timing is really important because it has direct implications on our timing of the out-of-Africa migration, as most non-Africans inherit 1-2% ancestry from Neanderthals.” This suggests significant migration events likely coincided with these interactions, tempering our previous assumptions about when modern humans first left Africa.

The archaeological evidence agrees, as artefacts and ancient remnants indicate both species coexisted for about 6,000 to 7,000 years, which coincides with the new genomic timelines. These interbreeding events suggest humans migrating out of Africa had already begun to mix with Neanderthals, aiding their adaptation to harsh Ice Age climates.

Neanderthal lineage survived remarkably through traces left within modern human genomes. Significantly, certain genes passed down from Neanderthals may have conferred advantages on early Homo sapiens. For example, genes related to immune responses, skin pigmentation, and metabolic processing are linked to Neanderthal ancestry and played pivotal roles as modern populations adapted to new environments.

One key takeaway from the studies is the concept of “Neanderthal deserts”—regions of modern human DNA lacking Neanderthal genes. Such deserts emerged rapidly following interbreeding, hinting at selective pressures where detrimental Neanderthal variants were weeded out—a stark indicator of how traits adapted through generations.

Leonardo Iasi, another co-author, articulated the need to view interbreeding as more than mere chance encounters, stating, “It was not just one event of interbreeding; rather, it reflects prolonged gene flow where groups of Neanderthals and modern humans interacted and mixed.” This aspect paints the Neanderthal-human interaction as complex and multi-faceted, likely varying across different communities.

Historically, these interactions have often been oversimplified. Neanderthals were frequently viewed as brutish and less civilized. The new age of research indicating rich, cross-species interactions raises intriguing questions about cultural exchanges or cooperative behaviors. Finding any archaeological evidence of joint tool use or shared habitats remains elusive, but stories stemming from genetic data might shed light on collaborations long after both species converged, creating legacies still present within our genes today.

While genetic studies suggest both species had the capability of interbreeding and producing fertile offspring, the varying evolutionary paths indicate periods of gene mixing must have involved more frequent contact. “We suspect mating between the two must have been common,” Joshua Akey, professor at Princeton, speculated, offering views alongside findings from multiple genes appearing beneficial over time.

An additional layer of complexity arises when examining the impacts of climate change and environmental pressures shaping these populations. During their time together, Neanderthals existed within the harsh realities of the Ice Age, successfully adapting to extreme climates and diseases. Their experience and genetic traits may have fortified modern humans, particularly those migrating from Africa.

Other evolutionary questions linger: How often did these two populations directly interact? What role did Neanderthal DNA continue to play as modern human populations migrated and changed culturally and geographically? Tom Björklund’s artistic interpretations of early human lifestyles serve as evocative illustrations of what these encounters might have looked like—two strands of humanity woven together against the backdrop of ancient Europe.

Analyzing the duality of our ancestral lines offers rich perspectives on survival and adaptability. Current research has established these interbreeding events as significant touchstones highlighting not only ancient human migration but also the resilience of our species, foreshadowing the complex interplay between adaptation and survival throughout human history.

Near 40,000 years ago, like many neighboring species, Neanderthals faced eventual extinction—possibly due to competition with modern humans or ecological shifts. The legacy of Neanderthals lives, albeit quietly, through the genes they left behind—a subtle reminder of the shared past featuring ancestral intermingling reshaping lineages.

So, as research continues to unearth the threads of our shared past, intriguing stories of ancient interbreeding remind us of the complex and interconnected paths leading to our modern human experience.