Prince Frederik of Nassau has tragically passed away at the young age of 22 after enduring a long battle with POLG Mitochondrial disease. The heartbreaking announcement was made by his father, Prince Robert of Luxembourg, who is the first cousin of Grand Duke Henri of Luxembourg.
Frederik died on March 1, 2025, but the family revealed the news publicly via the POLG Foundation's official website. This foundation, which Frederik was involved with as its founder and creative director, was established to raise awareness and support research concerning the rare genetic condition.
POLG Mitochondrial disease is known to rob the body’s cells of energy, leading to progressive multiple organ dysfunction and failure. Symptoms can vary but often include muscle weakness, epilepsy, and liver failure. Unfortunately, it wasn’t until Frederik was 14 years old, when his condition worsened, before he was officially diagnosed.
His father, Prince Robert, aged 69, and mother, Princess Julie of Nassau, aged 64, shared details about Frederik’s final hours. On February 28, known as Rare Disease Day, they shared how their son bravely asked to say goodbye to each family member, including his two siblings, Princess Charlotte and Prince Alexandre, as well as cousins and other close relatives. “He had already spoken all the heart he could to his extraordinary mother, who had not left his side for 15 years,” Prince Robert recounted. “Even at the end, he shared laughter with us. He had strength and courage, and it left us filled with love.”
Prince Robert described Frederik as his “Superhero” and highlighted his wonderful capacity for positivity and joy. “Frederik’s last question to me was: ‘Papa, are you proud of me?’ He needed reassurance about his life and contributions during his short time here,” he added, emphasizing the love they shared as a close-knit family.
Frederik was not only celebrated for his spirit but also for his dedication. Following his diagnosis, he wanted to make sure others did not have to suffer as he did. This passion led to the creation of the POLG Foundation, established to support research and promote awareness of the disorder. His efforts were not purely academic; they stemmed from personal experiences shared through storytelling. Just last September, the foundation released The PolG Foundation Film, aimed at raising awareness of the condition and its impact on affected families.
Frederik’s passing resonates deeply, especially following the abdication of Grand Duke Henri of Luxembourg, who stepped down from his role as monarch late last year, passing the throne onto his son, Prince Guillaume. This notable event, paired with the tragic loss of Frederik, marks significant moments for the Luxembourg royal family.
Prince Robert also expressed deep gratitude for the messages of love and support received following their tragically difficult time. “This is not just about our family’s grief, but about countless others who similarly struggle with conditions like POLG,” he explained.
Frederik’s lifetime was not defined by his illness. He was born with POLG Mitochondrial disease but embodied resilience and strength. He actively participated in crafting his legacy. “When we asked him if he wanted to create this foundation, he jumped at the opportunity immediately. He was driven to help others,” his father stated, indicating the prince’s selflessness and determination.
Many will recall his passion for music, film, gastronomy, and nature, interests he cherished deeply, shared among family and friends. Besides advocacy, Frederik was also known for his humor; he maintained light-heartedness even during challenging times, evident until the very end.
Born on March 1, 2002, Frederik’s life encompassed both triumphs and struggles. After celebrating his early years in London, he later moved to Geneva and attended several schools, shaping connections with various communities and individuals globally. His father highlighted how these experiences enriched Frederik’s appreciation of life, stating: “He always found beauty even amid challenges, often reflected through his gratitude.”
Grand Duke Henri expressed similar sentiments; he called Frederik “my superhero” during his tribute, remarking on Frederik’s capacity to inspire. He echoed sentiments shared by Prince Robert, highlighting how Frederik often expressed gratitude for his experiences, turning struggles with his disease to bridges of connection with others facing similar obstacles.
While Frederik’s battle is over, his legacy continues through the POLG Foundation and those he inspired along the way. His family intends to honor his memory by actively participating in the advocacy he was passionate about and ensuring the fight for cures persists even after his passing. “We will exhaust every effort turning our deep grief to positive results, just like Frederik did with his life. His message of hope and compassion will continue to guide us,” Prince Robert concluded.
The royal family has requested privacy as they mourn this significant loss and appreciate supportive gestures as they reflect on their time with Frederik.