The study establishes age- and sex-specific reference intervals for inhibin B levels in healthy Chinese children, aiding clinical assessment of reproductive health.
The study measures inhibin B levels in 622 healthy Chinese children, identifying reference intervals based on age and sex, which are important for diagnosing reproductive health issues.
Researchers from Wuhan Children’s Hospital conducted the study, with contributions from multiple authors including Bin Zhou and Jinjun Luo.
The study was conducted from January to December 2022 and published on 2025-03-23.
Research conducted at Wuhan Children’s Hospital, Wuhan, China.
There was previously no established reference data for inhibin B levels specific to Chinese children, impacting clinical diagnostics.
The researchers used the KAESER 1000 chemiluminescence analyzer to measure serum inhibin B, FSH, LH, and other hormones across four age groups.
The study also found significant sex differences, with girls showing lower median levels of inhibin B compared to boys across all age groups.
"INHB level is influenced by age and sex, and our results provide specific RIs to facilitate screening sexual function diseases in Chinese children."
"The optimal models for the effect of age on INHB were cubic."
1. Introduction: Introduce the significance of inhibin B as a biomarker and the necessity for reference intervals for clinical assessment of children's reproductive health.
2. Background: Discuss the relevance of inhibin B and highlight the lack of age-specific reference intervals and its importance for diagnostics.
3. Methodology and Discovery: Explain the study methodology, describing the sample collection and the use of the chemiluminescence analyzer to obtain results.
4. Findings and Implications: Present the key findings on INHB levels by age and sex, underscoring their clinical relevance for monitoring children's reproductive health and potential applications.
5. Conclusion: Summarize the importance of established reference intervals and their future application, emphasizing the continuing need for research to refine these measures and improve clinical outcomes for children.