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16 March 2025

New Scoring System Enhances Prediction Of Mortality Risk For STEMI Patients

A two-stage scoring model shows promise for improving rapid assessment and management of ST-elevation myocardial infarction outcomes.

A new study has unveiled a two-stage scoring system for predicting 30-day mortality among patients suffering from ST-elevation myocardial infarction (STEMI), representing significant advancements to the existing risk assessment frameworks.

Conducted across 66 hospitals and involving 3939 patients, the research addressed the glaring issues with current risk scores, which often fall short on timeliness, feasibility, and accuracy. By focusing on factors readily available at first medical contact, the scoring system aims to improve early identification of high-risk patients and streamline management decisions.

The study's senior researchers, driven by the importance of rapid response and high-quality management, found existing systems like the TIMI risk score and GRACE score lagged due to their reliance on laboratory results, leading to delays. To confront this challenge, researchers separated the scoring system development process, ensuring the first medical contact risk score utilized easily obtainable variables—age, gender, systolic blood pressure, heart rate, Killip class, and the presence of anterior myocardial infarction.

“This newly developed scoring system enables faster and more efficient clinical decision-making right from the start of treatment, addressing pressing challenges faced by STEMI patients, particularly those presenting at less equipped medical facilities,” said one of the authors of the study.

The study randomized 3939 STEMI patients, with 2757 assigned to derivation datasets and 1182 to internal validation datasets. An independent cohort of 1315 patients was employed for external validation, ensuring the robustness of findings.

The research team achieved impressive predictive accuracy with the newly proposed risk scores. Results indicated the first medical contact risk score had equivalent predictive capacity to established models, and results from internal validation confirmed the model's reliability, with area under the curve (AUC) measures of 0.816 for the FMC stage and 0.854 for the in-hospital stage.

Notably, the integration of serum creatinine levels and left ventricular ejection fraction (LVEF) was shown to bolster the predictive capabilities of the system during the hospital stay, returning AUC scores of 0.843 and 0.876, respectively.

“Our findings also indicated this scoring system demonstrated enhanced discrimination and calibration when compared directly with the classic risk scores, promising significant benefits to patient care,” the authors emphasized.

Over the course of the study, 352 individuals—roughly 8.9%—lost their lives within 30 days of the first medical contact, including 9.1% from the derivation datasets and 8.6% from the internal validation datasets, underscoring the imperative need for effective real-time assessments.

This two-stage scoring model brings to the forefront the reality of clinical practices, particularly within China, where patients often encounter delays due to inefficient referral processes and variable facility capacities. Current classic scores may not reflect the unique demographic and clinical challenges faced by the Chinese population.

“The health care infrastructure gaps can hinder the rapid and effective implementation of guideline-recommended strategies,” said one of the leading researchers. “By using our scoring system, clinicians can identify high-risk patients rapidly and adjust treatment protocols accordingly.”

The research trial spanned from September 2016 to August 2018, with external validations occurring between November 2019 and March 2020. The dynamic nature of their scoring system suggests regular assessments can yield vastly improved patient outcomes.

Looking to the future, the authors express hope the implementation of machine learning algorithms integrating this scoring system could lead to even more refined and effective risk assessments, ensuring all patients receive the best possible care.

Earlier methodologies, including the TIMI risk index and GRACE score, have been adapted and modified, yet the two-stage system presents far-reaching advantages as it serves the pressing need to adapt risk assessments to modern clinical settings.

With impressive effectiveness verified through rigorous statistical analyses and extensive patient datasets, the authors firmly believe this innovative approach will allow for improved management strategies of high-risk STEMI patients across health care settings.

The results of this important study are published and can serve as a blueprint for health care systems aiming to modernize their risk assessment tools and improve early treatment decisions for STEMI patients.