The study focuses on multi-omics analyses to reveal biological and clinical insights associated with post-operative recurrence of stage I non-small cell lung cancer.
The study investigates genomic, epigenomic, and transcriptomic profiles of tumors from 122 stage I NSCLC patients, highlighting factors associated with post-operative recurrence.
Conducted by researchers at West China Hospital, Sichuan University, including multiple authors from the institution.
Research was conducted from 2014 to 2020, with follow-up data until August 2024.
All patient data and samples were collected at West China Hospital, Sichuan University, China.
The motivation behind this research is to address post-operative recurrence rates of 20-40% and the need for molecular insights to guide clinical management.
The study utilizes whole-exome sequencing, RNA sequencing, and single-cell RNA sequencing to analyze the fusion of diverse omics data, aiming to find recurrent patterns related to lung cancer.
This study provides significant insights for potential therapeutic strategies and establishes PRAME as a key gene involved in recurrence.
Our study provides insights enabling future research on stage I NSCLC recurrence to investigate biological mechanisms and explore therapeutic strategies.
We hope these findings will contribute to more effective recurrence risk stratification and precise therapy after surgery.