The Grand Duchy of Luxembourg is mourning the untimely loss of Prince Frederik, who passed away at the age of 22 after bravely battling a rare genetic disorder known as the PolG mutation. His family announced the tragic news, which has deeply affected the royal household and the Luxembourgish community.
Prince Frederik, the son of Prince Robert of Luxembourg and Princess Julie de Nassau, died on March 7, 2025, at a Paris hospital. He had been diagnosed with the PolG mutation, which affects energy production at the cellular level, leading to progressive organ failure. The announcement of his passing came just days after he was laid to rest, marking the end of his nine-year struggle against the debilitating condition.
Describing his son’s strength, Prince Robert said, "Frederik found the strength and courage to say goodbye to each of us one after another." This emotional farewell took place shortly before his passing and was characterized by Frederik's characteristic humor, where he left his family with one final joke to lighten their spirits.
Diagnosed with the PolG mutation at the age of 14, Frederik faced numerous challenges throughout his teenage years. Symptoms included balance and coordination issues, which progressively incapacitated him. His father shared, "This is the battle Frederik fought, and this is the burden he had to carry his whole life. He did it always with grace and humor." These words reflect not only the family's deep love and admiration for Frederik but also his indomitable spirit and ability to bring joy even during hardship.
Family members fondly recalled moments with him, stating he was recognized for his amazing humor and strong character. Prince Robert noted, “Even in his last moments, his humor and boundless compassion forced him to leave us with one last laugh... to cheer us all up.” Such memories encapsulate the essence of who Frederik was—a young man who cherished his family and faced immense challenges with bravery.
The Royal family established the POLG Foundation with the goal of raising awareness about rare diseases, particularly the one affecting Frederik. They aim to provide support for research and treatment options for those suffering from mitochondrial disorders. The foundation's initiatives have not only focused on scientific research but also emphasized the importance of recognizing these conditions within society. Prince Robert commented on the privilege their family had to seek medical expertise and support, stating, “My family had the significant advantage because of my father-in-law’s career, allowing us easier access to the medical world for Frederik's diagnosis.”
The public share of their pain and advocacy efforts have drawn attention to rare genetic disorders like the PolG mutation, which are often hidden from the broader public consciousness. “We must give hope to those who are fighting similar battles,” Prince Robert emphasized, “and Frederick’s spirit will drive our mission forward.”
Frederik was not merely defined by his illness but also as someone who contributed meaningfully to his community. His work on the foundation’s logo and website development showed his commitment, and many admired how he transformed his suffering and hardships to inspire others. His family recalled how he took part proudly, designing clothing lines to generate awareness and support for the foundation; this showed his desire to remain engaged with life and those around him.
While the loss of Prince Frederik leaves behind immense sorrow, his legacy, spirit, and the mission his family continues to champion will not be forgotten. The Grand Duchy of Luxembourg will honor him, keeping his memory alive through continued advocacy and hope.