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18 December 2024

Global Mpox Outbreak Sparks Urgent Vaccine Initiatives

Countries intensify response efforts as cases rise and fatalities reported.

MANILA, Philippines — The Philippines recorded its first mpox fatality since August, adding to the growing concern as the nation manages 52 reported cases to the Department of Health (DOH). During a media forum on December 16, Health Secretary Teodoro Herbosa explained the direct cause of death was attributed to comorbidity rather than mpox itself. While the DOH has not released specific details about the deceased patient, Herbosa noted recovery statistics among the infected, indicating 28 patients have regained health, leaving 23 as active cases currently undergoing home isolation.

The geographical distribution of mpox cases within the Philippines shows many cases emerge from the National Capital Region, where 33 infections have been identified. Calabarzon has 13 cases, Central Luzon three, Cagayan Valley two, and Central Visayas registering one case. Notably, Herbosa pointed out the concerning statistic: about 30 percent of mpox patients are individuals living with HIV (human immunodeficiency virus), who are particularly vulnerable due to their compromised immune systems. Ranging from infants to seniors, the youngest patient is just six months old and the oldest is 66 years. "None of the 52 mpox patients have the more severe Clade Ib variant," Herbosa assured, highlighting they belong to Clade II, which tends to be less severe and self-limiting.

Since declaring mpox as a public health emergency of international concern (PHEIC) back in August 2024, the World Health Organization has maintained heightened vigilance as new cases and fatalities arise worldwide. The total global case count since the start of 2024 has exceeded 65,700, with roughly 1,200 deaths reported, significantly affecting the Democratic Republic of the Congo (DRC). A new variant, the Clade 1b, has haunted health officials due to its increased virulence and higher mortality rates, especially among children.

Addressing the urgency of the situation, Adar Poonawalla, CEO of the Serum Institute of India, announced on December 15, 2024, their collaboration with Bavarian Nordic A/S. This Danish biotechnology firm has committed to transferring production technology to the Serum Institute, thereby enabling local manufacturing of mpox vaccines for the Indian market. Poonawalla emphasized, "By leveraging our manufacturing expertise and rapid response capability, we aim to expand access to life-saving vaccines and protect vulnerable populations from mpox." The initiative arises amid the global health challenge posed by the mpox outbreak.

Paul Chaplin, President and CEO of Bavarian Nordic, echoed the sentiment of urgency and corporate responsibility, stating, "Although there are currently no capacity constraints, scaling global manufacturing is...vital to ensuring equitable access to vaccines worldwide." The partnership is grounded on shared profitability, amplifying production capacity to tackle the pressing health crisis. Following WHO’s declaration, nations like Rwanda and the DRC have initiated vaccination drives targeting high-risk groups, aiming to stem the tide of this rapidly spreading virus.

On the ground, health agencies are encouraging communities to engage actively to avert mpox's spread. Uganda’s Ministry of Health noted over 1,000 confirmed cases since the outbreak announcement, escalated by weekly reports of 17 new infections. The situation worsened with six deaths reported, compelling the government to enact public health measures across 57 districts. Notably, Kampala has emerged as the epicenter of the epidemic, requiring intensified public health communication efforts as the community is educated about preventative measures. Campaigns broadcast through radio stations and television have become standard measures to curtail misinformation about the disease.

Meanwhile, Germany's response has been proactive as well, with the German state of North Rhine-Westphalia shuttering schools after two children tested positive for mpox. Authorities there observed the presence of the Clade 1b variant and decided to transition affected classes to online learning to safeguard student wellbeing. Spreading primarily through close contact, German health officials continue to remind citizens of proper hygiene and risk awareness, reinforcing community cooperation with healthcare providers to lessen the infection’s potential.

The collective situation highlights the pressing need for global vigilance and swift action against mpox. Prevention, awareness, and vaccination stand at the forefront of effective response strategies. Governments and health organizations anticipate the new year with renewed optimism, aiming to fortify populations against mpox resurgence as these intensified efforts take flight.

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