Cinnamomi cortex, commonly known for its medicinal properties, has shown promising effects on the circadian rhythms of skin cells, according to recent research conducted by scientists at Pusan National University. Their study highlights how components derived from this extract, particularly epicatechin (EC) and linalool (LO), have the potential to modulate skin physiology and promote overall skin health.
Circadian rhythms are 24-hour cycles intrinsic to various physiological processes, including those necessary for skin homeostasis. The disruption of these rhythms is linked to several skin disorders, leading to compromised barrier functions and accelerated aging. This study set out to investigate whether the cinnamomi cortex extract could positively influence the circadian rhythms of keratinocytes, the primary cells found within the skin.
Using human keratinocyte cell lines, researchers found significant improvements. The CC extract and its components, EC and LO, increased the circadian amplitude without affecting the rhythmic period, signaling their potential for therapeutic applications. The introduction of CC extract enhanced bioluminescence activity, indicating increased circadian rhythm strength. Research has pointed out, "CC extract significantly increased the amplitude of circadian rhythms," demonstrating the extract's capability to support skin resilience against environmental stressors.
To elucidate the mechanisms behind these effects, the research team conducted extensive gene expression analyses, examining clock genes fundamental to circadian rhythm regulation. They discovered variations including decreased levels of the gene CRY1 and increased levels of BMAL1 and PERIOD 2 after treatment with CC extract. These alterations suggest reprogramming of the cellular circadian clock, potentially leading to enhanced clock function.
The researchers also utilized molecular docking simulations to explore the interaction of EC and LO with the RORA protein, key for circadian control. The results confirmed strong binding affinities, with both EC and LO exhibiting high potential to influence gene transcription related to circadian function. Notably, the study reported, "Both EC and LO exhibited strong binding affinities for RORA, a key nuclear receptor involved in circadian regulation." This insight lays the groundwork for integrating botanical extracts as circumstantial treatments for skin health.
Beyond merely modulating circadian rhythms, the findings suggest substantial antioxidant activities linked to EC and LO. The study indicates these compounds reduced oxidative stress, protecting skin cells from reactive oxygen species. Remarkably, EC's treatment increased the expression levels of key antioxidant enzymes, showcasing their multi-functional role within keratinocytes.
The enhanced information on the skin barrier function was also noted. The CC extract, particularly through its specific components EC and LO, was found to significantly increase the expression of ceramide synthesis genes, thereby promoting the skin's protective barrier against environmental threats. The research concluded this aspect with, "The findings highlight the potential of CC extract and its components as novel dermatological treatments to improve skin health and combat aging."
Overall, the innovative research conducted demonstrates the extensive potential of cinnamomi cortex extract and its active constituents. The regulation of skin circadian rhythms signifies not only improvements for skin health but may alter approaches to treating age-related skin conditions. The authors encourage future exploration of CC extract's mechanisms, emphasizing the need for continued investigations using 3D skin models to simulate natural interactions more accurately.