The potential of Chrysanthemum morifolium flower extracts as safe and effective ingredients for cosmetic applications due to their bioactive compounds and safety profiles.
This study analyzed the phytoconstituent composition, antioxidant activity, anti-glycation, anti-collagenase properties, and safety evaluation of purple, yellow, and white Chrysanthemum morifolium flower extracts using hydroglycolic solvent extraction. The research was conducted by the authors of the article, affiliated with the Faculty of Pharmacy at Mahidol University and supported with funding from the Thesis Grant of the Faculty of Graduate Studies, Mahidol University. The study was published and available for reference on March 6, 2025. The flower samples were obtained from Saraburi Province, Thailand. With rising consumer preferences for natural active ingredients over synthetic ones, this research aims to evaluate the efficacy and safety of natural products from Chrysanthemum morifolium for cosmetic use. The researchers employed hydroglycolic solvent extraction, followed by various assays to assess antioxidant activity (DPPH and ABTS assays), anti-glycation activity, anti-collagenase activity, and skin irritation tests using reconstructed human epidermis. Luteolin and chlorogenic acid were identified as key compounds, with purple extracts showing the highest concentrations; safety evaluations indicated no skin irritation or sensitization.
“These preliminary findings suggest the potential of C. morifolium flower extracts, particularly from yellow and purple varieties, as a promising ingredient in plant-based formulations.” While the RhE model offers valuable preliminary safety data, it is important to recognize the limitations of this in vitro system. A previous study evaluated and compared the inhibitory effects of the aqueous extracts of Chrysanthemum species, especially C. indium and C. morifolium, on the formation of AGEs.
Present the significance of the study focusing on increasing consumer demand for natural cosmetics and the advantages of using C. morifolium extracts.
Discuss the historical use of C. morifolium flowers, their medicinal properties, and the relevance of phytochemical research.
Detail the extraction process with hydroglycolic solvents, the assays performed to evaluate antioxidant and bioactive properties, and the safety evaluation methods used.
Report on the significant findings such as high total phenolic and flavonoid contents, antioxidant activities, and safety results indicating no skin irritation, indicating the extracts' suitability for cosmetics.
Summarize the findings and propose the need for future clinical studies to validate the efficacy and safety of C. morifolium extracts for human cosmetic applications.