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20 July 2024

Can The New Malaria Vaccine Curb Africa's Deadly Scourge?

Health workers in Ivory Coast begin administering a new malaria vaccine to children, sparking hopes of reduced disease impact across Africa

Those tiny mosquitoes, often overlooked in the chaotic buzz of everyday life, are responsible for one of the globe's most deadly diseases: malaria. Health workers in Ivory Coast have embarked on a pioneering mission starting Monday, administering a cutting-edge vaccine to children. This initiative is seen as a beacon of hope in the ongoing fight against malaria, which remains a top killer in Africa.

Ivory Coast has become the first nation to roll out this advanced malaria immunization. Developed by Britain’s Oxford University, the R21/Matrix-M vaccine has received the green light from the World Health Organization (WHO). This new vaccine, which requires three doses, promises to shield children from severe malaria symptoms with over 75% efficacy in the first year, extending its protection for at least another year with a booster.

For mothers like Alice Kanga, this vaccine campaign is more than just a health measure—it's a lifeline. As she held her child during the vaccination drive, Kanga reflected on the significance of this medical advance. “It’s really important for the children, for their health,” she said, encapsulating the hopes of many parents in the region.

The WHO introduced its initial malaria vaccine, Mosquirix, in 2021, produced by GSK. Despite its groundbreaking nature, Mosquirix presented challenges: it required four doses, its protection waned fast, and production was limited to approximately 15 million doses.

In contrast, the Serum Institute of India, collaborating on the R21 vaccine, has already ramped up production, achieving more than 25 million doses and projecting an annual output of at least 100 million doses, each priced at around $4. This cost-efficiency and scalability promise to make a substantial dent in malaria's grip on the continent.

The stakes are high. Africa contends with over 94% of the world's 249 million malaria cases and 608,000 annual deaths, predominantly affecting children under five and pregnant women. Spread by the Anopheles mosquito, malaria’s parasitic nature has long made it a formidable adversary in public health.

Ivory Coast's health minister, Pierre Demba, underscored the government's dedication to the country's youth. “They are the future of our country,” he remarked, resonating with the sentiment that health investments are foundational for national development.

Adrian Hill of Oxford University echoed this optimism, declaring the launch of the R21 vaccine as a “new era in malaria control.” He emphasized the broader vision to make this vaccine accessible across Africa, igniting hopes of a broader continental shield against malaria.

However, while the new vaccine is a milestone, experts caution that it is not a solitary solution. As the disease doesn't stop spreading with vaccination alone, the integration of other measures—such as insecticide-laden nets, potent treatments, and widespread spraying—remain critical components of the anti-malaria arsenal.

The malaria vaccine alliance, Gavi, has worked to ensure that vaccines reach the most vulnerable populations. Countries such as the Central African Republic, Chad, and South Sudan have already received shipments of the Oxford-developed shot, marking a pan-African solidarity in combating the disease.

Reflecting on the efforts, it becomes clear that this vaccination campaign is more than a health initiative—it represents hope, resilience, and a collective push towards a future where malaria's shadow is drastically diminished. As the vaccines find their way to more children across the continent, the dream of a malaria-free Africa steps closer to reality.

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