The Houston Astros are gearing up for a pivotal midweek showdown as they face off against the Arizona Diamondbacks at Chase Field in Phoenix, Arizona, on Wednesday, July 23, 2025, with first pitch scheduled for 3:40 p.m. ET. This interleague matchup promises plenty of intrigue, featuring key player prop bets, pitching duels, and betting odds that have caught the attention of baseball fans and bettors alike.
Coming into this contest, the Astros hold the slight edge as favorites with -120 odds, while the Diamondbacks are underdogs at +100. The over/under is set at 8.5 runs, with balanced odds of -110 on both sides, reflecting the expectation of a competitive and tightly contested game. Fans can catch the action live on MLB Network, ARID, and SCHN, or stream it via Fubo, subject to regional restrictions.
On the mound, the Astros will start Brandon Walter, who sports a 1-3 record this season. Opposing him is Arizona's Brandon Pfaadt, boasting an impressive 10-6 mark. Both pitchers will be under the microscope as they try to contain the opposing offenses in what could be a low-scoring affair.
The Astros' lineup features standout Jose Altuve, whose player props are a focal point for bettors. Altuve is over/under 1.5 hits with odds of +175 for the over and -227 for the under. He also has runs, home runs, and RBI props set at 0.5, each with varying odds. Altuve has been a consistent performer this season, hitting .280 with a .340 on-base percentage and a .466 slugging percentage, compiling 17 home runs, 53 RBIs, six stolen bases, and 55 runs scored. His recent games show a steady hand, including a 2-for-4 performance with a run and a walk against the Diamondbacks on July 22.
Yainer Diaz also draws attention with his prop bets. Over 359 plate appearances, Diaz holds a .241 batting average with a .273 OBP and a .394 slugging percentage. He's knocked 13 home runs with 34 runs and 39 RBIs. Diaz's recent 2-for-5 showing at Chase Field on July 22 adds to his appeal for bettors looking at his hits and runs props.
For the home side, Geraldo Perdomo is a key figure. His over/under for hits is set at 0.5 with odds of -222 for the over and +165 for the under. Perdomo's slash line of .275/.375/.420 has been instrumental for the Diamondbacks, as he has tallied 10 home runs, 72 RBIs, 55 runs, and an impressive 15 steals on 18 attempts. His recent 3-for-4 game versus the Astros on July 22 highlights his offensive threat.
Eugenio Suárez rounds out the Diamondbacks' notable batters, with prop bets on hits, runs, home runs, and RBIs all set at 0.5. Suárez's power is evident in his .254/.325/.598 slash line, featuring 36 home runs and 86 RBIs. Though he went 0-for-4 with three strikeouts on July 22, his prior performances, including a home run and RBI on July 21, keep him in the spotlight.
Betting experts have weighed in on this matchup. While the Astros are favored in the player props and moneyline, some systems suggest a lean toward the under 8.5 total runs. This prediction is based on a model targeting unders in interleague games between winning clubs with modest totals, especially when the home team is favored. The system has an 8% return on investment lifetime and has cashed picks at a 53% clip this season, lending credibility to the under bet.
Just a day later, the Houston Astros will host the Oakland Athletics at Minute Maid Park in Houston for the opener of a four-game series on Thursday, July 24, 2025, at 8:10 p.m. ET. The Astros have been on a roll, winning four straight games and leading the AL West by six games over the Seattle Mariners. They recently completed a three-game sweep of the Diamondbacks, with a thrilling 4-3 win on July 23, highlighted by DH Christian Walker's game-winning RBI single in the ninth inning.
The Athletics, meanwhile, have struggled since the All-Star break, dropping four in a row and going 1-5 in that span. They enter the series with a 42-62 record, while the Astros boast a strong 60-42 mark. The season series between these two teams currently favors the Astros 4-2.
The pitching matchup for Thursday features Athletics' right-hander Luis Severino (3-11, 5.10 ERA) against Astros' Jason Alexander (1-0, 8.40 ERA). Severino, known for his 95.3-mph fastball velocity—ranking in the 83rd percentile among starters—has been given more leeway this season with 5.5 more adjusted pitches per outing than average. However, his strikeout numbers are less impressive, with a 6.7% swinging strike rate (2nd percentile) and a 16.6% strikeout rate (11th percentile).
Minute Maid Park is notable for its pitching-friendly environment. Ranked as the third-best field for strikeouts by the projection system THE BAT, its low altitude (just 20 feet above sea level) and closed roof—expected to make conditions 15 degrees colder than average—favor pitchers. The park also has the third-tallest average fence height and is projected as the 10th-worst field for batting average, which could suppress offense further.
The Athletics boast the second-strongest infield defense among teams playing that day, which could challenge the Astros' hitters. Despite these factors, betting predictions favor the Astros to win the opener with a 5-4 scoreline and recommend wagering on the Astros moneyline at -125 and the over 8 total runs at -115, anticipating a competitive and moderately high-scoring game.
As the Astros prepare for this critical stretch of games, their recent form has been encouraging. Brandon Walter's strong pitching performance on July 23, where he threw seven innings with only one earned run, four hits, one walk, and five strikeouts, helped secure the win against the Diamondbacks. Relievers Bennett Sousa and Josh Hader also contributed, with Hader recording his 27th save.
Meanwhile, the Athletics will look to bounce back from their recent struggles. Luis Severino's last start saw him snap a five-start losing streak with a solid five-inning, two-run performance against the Cleveland Guardians on July 19. However, his career record against the Astros is challenging, standing at 2-5 with a 4.82 ERA.
Overall, the upcoming games highlight the Astros' pursuit of maintaining their strong position in the AL West and their momentum from recent victories. Meanwhile, the Diamondbacks and Athletics seek to halt their respective slumps and gain ground in their divisions. Fans and bettors alike should keep a close eye on player performances, pitching matchups, and game conditions as these pivotal MLB contests unfold.
