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Science
09 July 2024

Can IVF Save Endangered Rhinos?

Scientists pioneer groundbreaking IVF techniques to rescue critically endangered rhino species from the brink of extinction

Imagine a massive two-ton rhino gently sedated, ready to undergo a procedure as delicate as harvesting eggs. This scenario, although seemingly improbable, stands at the forefront of a scientific marvel aiming to preserve a species. Conservationists across the globe are collaborating with zoos and scientists to leverage cutting-edge fertility techniques to protect the dwindling population of rhinos. The urgency for this intervention stems from the severe reduction in their numbers due to rampant poaching and habitat loss.

Recently, scientists from Berlin achieved a ground-breaking milestone. They successfully transferred an embryo into a southern white rhino, marking the world's first IVF rhino pregnancy. The implications of this achievement could be monumental, providing hope for the critically endangered northern white rhino.

Rhinos, particularly the northern white subspecies, are on the brink of extinction. With only two female northern white rhinos left, none of which can carry a calf to term, IVF represents a beacon of hope. Notably, the international BioRescue team has been racing against time to save these magnificent creatures.

The process isn’t exactly a walk in the park. Harvesting eggs from a giant rhino involves precision akin to that of a brain surgeon but on a much larger scale. Take Zanta, a 22-year-old southern white rhino residing in Dublin Zoo. Zanta’s genetic makeup is deemed invaluable, but previous reproductive assessments revealed she couldn’t breed naturally. Utilizing IVF, Zanta’s genes can contribute to future generations. A team from the Leibniz Institute for Zoo and Wildlife Research (IZW) in Germany facilitated this complex procedure, flying to Ireland to perform the egg extraction.

Upon her sedation, the team worked meticulously, guided by ultrasound imaging to locate and extract her eggs. The scientists not only showed commendable expertise but highlighted the delicate balance between advancing technology and respecting wildlife.

In January, the team announced a significant breakthrough when an embryo transfer led to a successful pregnancy in a surrogate southern white rhino. Though this pregnancy did not result in a live calf due to an unrelated bacterial infection, it demonstrated that the technique was feasible. The next mission is even more ambitious: applying this technology to the near-extinct northern white rhinos.

The northern white rhinos’ plight began due to extensive poaching and habitat destruction, reducing their once vast numbers to just a pair of females. Neither can naturally carry a pregnancy. By utilizing stored sperm from deceased males and viable eggs from the females, scientists aim to create viable embryos. The embryos would then be implanted into surrogate southern white rhino mothers, giving a potential lifeline to the northern subspecies.

Thomas Hildebrandt, a reproductive expert at Leibniz IZW and a central figure in the BioRescue team, shared his optimism, "We achieved together something which was not believed to be possible. This is really a milestone." This achievement sets the stage for potentially saving the northern white rhino from its grim fate.

The vision extends beyond merely preserving these two northern white rhinos. It's about sustaining biodiversity to withstand potential threats such as diseases, which can be devastating in genetically uniform populations. Hildebrandt explains, "If you have a very narrow gene pool, a virus, for example, can jump from one individual to another because each individual's immune system acts the same." A genetically diverse population is crucial for resilience.

The groundwork laid by these recent successes promises broader applications. Conservationists are eyeing possibilities to help other critically endangered species like the Sumatran rhino, with fewer than 100 individuals remaining.

The efforts at Dublin Zoo with Zanta, backed by technological prowess from institutions like Leibniz IZW, epitomize a harmonious blend of science and empathy. This cooperation reaches a crescendo when viewing the lab setups adjacent to rhino enclosures, housing microscopic cells with the potential to grow into massive, two-ton behemoths.

The resilience and adaptability of these mammoth creatures are echoed in the methods used to preserve them. IVF attempts include using a "teaser" bull to simulate natural mating behaviors, thereby enhancing the likelihood of successful embryo transfers. Despite tragic setbacks, such as the deaths of promising surrogate mothers, the research continues with renewed vigor and adjusted techniques.

One can't help but marvel at the sheer persistence and innovative spirit driving these conservation efforts. From meticulously harvesting eggs in sterile lab conditions to the hopeful planning of introducing newborn calves into the wild, every step is a delicate dance orchestrated by committed scientists and conservationists.

As the BioRescue consortium refines its processes, there’s a palpable sense of urgency and hope. With 30 northern white rhino embryos currently preserved, the team plans to accelerate their attempts to transfer these embryos into suitable surrogates. Success in these endeavors could see northern white rhino calves being born within the next couple of years.

The outcome of these cutting-edge efforts extends beyond zoological significance. They signal a shift in how technology interacts with wildlife conservation, blending advanced biotechnology with the timeless goal of preserving Earth's biodiversity. The journey of Zanta, from a simple zoo resident to a key player in a global conservation strategy, embodies this intricate dance between nature and technology.

As the world watches, the hopes of reviving the northern white rhino species rest on the unprecedented fusion of science and dedication. If a few precious embryos implanted in surrogate mothers can indeed spark the rebirth of a subspecies, it would be a triumph not just for rhinos but for conservation as a whole. Hildebrandt optimistically summarizes, "This is a great milestone in the preservation of the northern white rhino genetic lineage."

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