The NFL’s Week 6 slate is always one of the most anticipated stretches of the season, and 2025 is no exception. With crucial matchups, playoff implications, and a few teams eager to prove themselves after recent setbacks, fans across the country are in for a football feast. Let’s take a deep dive into the most buzzed-about games, predictions, and the storylines shaping this pivotal week.
Sunday’s action kicks off bright and early, as the Denver Broncos square off against the New York Jets in London at 6:30 a.m. MST. According to The Arizona Republic, the Broncos are expected to come out on top with a 27-17 victory over the Jets, setting the tone for a day packed with high-stakes football. International games always add a layer of unpredictability—will the time zone change and unique atmosphere throw off either squad?
The early window features several intriguing contests. The Los Angeles Rams travel to face the Baltimore Ravens at 10 a.m. MST, with predictions favoring the Rams 31-20. Meanwhile, the Dallas Cowboys are slated to take on the Carolina Panthers, with the Cowboys expected to edge out a 28-20 win. The Arizona Cardinals are on the road against the Indianapolis Colts, and if the experts are right, the Colts should secure a 28-17 victory.
One of the closest projected games pits the Seattle Seahawks against the Jacksonville Jaguars. The Seahawks are slight favorites, predicted to win 24-23. Over in Miami, the Los Angeles Chargers are picked to narrowly defeat the Dolphins, 27-24. The Cleveland Browns, coming off a turbulent start to the season, face the Pittsburgh Steelers, with the Steelers expected to claim a 24-14 win. In New Orleans, the Patriots are predicted to best the Saints 24-20, a matchup that could have major AFC playoff implications down the line.
As the afternoon unfolds, the Tennessee Titans visit the Las Vegas Raiders at 1:05 p.m. MST, where the Raiders are tipped to win 23-21. The San Francisco 49ers head to Tampa Bay for a showdown with the Buccaneers. This one looks to be a shootout, with the Bucs narrowly favored 30-27. Meanwhile, the Cincinnati Bengals face a daunting challenge as they travel to Lambeau Field to take on the Green Bay Packers at 1:25 p.m. MST.
This Bengals-Packers clash is one of the day’s marquee matchups. Kickoff is set for 4:25 p.m. ET (1:25 p.m. MST) and will be broadcast nationally on CBS, with streaming available via NFL+. Entering the game, the Packers boast a 2-1-1 record, while the Bengals are looking to rebound from a 2-3 start. According to The Arizona Republic, the Packers are favored by a wide margin, with a predicted 31-13 victory over Cincinnati. The Bengals will need to dig deep if they hope to upset the odds at the storied Lambeau Field.
Fans wondering how to catch the action won’t have to look far—the game will be available on CBS and NFL+, ensuring that no one misses a snap of this crucial NFC-AFC showdown. The Packers’ balanced attack and home-field advantage give them the edge, but the Bengals have shown flashes of brilliance this season. Could this be the week Cincinnati finds its groove?
As Sunday night approaches, the Detroit Lions are set to face the defending champion Kansas City Chiefs on NBC’s Sunday Night Football. The Lions are predicted to stun the Chiefs with a 34-24 win, a result that would send shockwaves through the league and signal Detroit’s arrival as a legitimate contender. The Chiefs, however, have a knack for primetime heroics—don’t count them out until the final whistle blows.
Monday Night Football caps off Week 6 with the Buffalo Bills traveling to Atlanta for a highly anticipated battle against the Falcons at Mercedes-Benz Stadium. This marks Atlanta’s first Monday night home game since 2017, adding an extra layer of excitement for Falcons fans. The Bills, led by quarterback Josh Allen, are looking to bounce back after suffering their first loss of the season to the New England Patriots just a week prior. Despite the setback, Buffalo remains atop the AFC East and tied for the best record in the conference.
Allen, who racked up 306 total yards but turned the ball over twice in the previous game, acknowledged the team’s need to refocus. “Obviously, we didn’t play as well as we would have liked to play this last week and that’s going to happen when you lose the football game,” Allen told reporters. “I think it’s a wakeup call, a reset, whatever you want to call it. We had been getting by previous games of maybe not playing our best football, and when you play a (Patriots) team that, again, did everything the right way, and credit to them for coming into our home stadium and having a really good game plan. It does wake you up in terms of, ‘Hey, every week we’re going to get the team’s best, whoever we’re playing’s best and we have to play up to our standard.’ At the end of the day, this is the NFL, each and every week has got to be earned.”
On the other side, the Falcons are still searching for their identity under coach Raheem Morris. They enter the game with a 2-2 record, having shown both flashes of promise and bouts of inconsistency. Quarterback Michael Penix, making his eighth career start, faces a tough test against a Bills defense eager to redeem itself. Notably, Atlanta’s defense leads the league in passing yards allowed per game (135.0), thanks in part to an aggressive blitzing approach. Can Penix and the Falcons capitalize on home-field advantage in their first Monday night home appearance in eight years?
The game is predicted to be a nail-biter, with experts giving the edge to the Bills, 26-24. But as any NFL fan knows, predictions are just that—anything can happen under the bright lights of Monday Night Football. The Bills’ tight end Dalton Kincaid, despite dealing with an oblique injury, could be a difference-maker if he’s able to suit up, while the Falcons will rely heavily on running back Bijan Robinson, who leads the NFL with 146.0 yards from scrimmage per game.
Elsewhere around the league, teams are jockeying for position as the playoff picture slowly comes into focus. The Patriots, Steelers, and Rams are all looking to build momentum, while the Jaguars, Dolphins, and Saints aim to get back on track. Every snap, every drive, and every decision carries weight as the season barrels toward its midpoint.
As the dust settles on another action-packed NFL weekend, fans are reminded why football remains America’s favorite sport. With so many games coming down to the wire and unexpected twists at every turn, Week 6 is shaping up to be a classic. Stay tuned—because in the NFL, the only certainty is unpredictability.
