Orioles And White Sox Face Off In Chicago Showdown

The Chicago White Sox and Baltimore Orioles are set to square off under the lights at Rate Field on Monday, September 15, 2025, with first pitch scheduled for 7:40 p.m. EDT. Both teams enter the contest with plenty to prove and a host of storylines swirling around their lineups, pitching matchups, and recent form. The game will be broadcast on CHSN and MASN2, ensuring fans across the country can tune in for every pitch, swing, and dramatic moment as these two American League clubs battle it out in the Windy City.

For the Orioles, this series opener comes at a pivotal time. Baltimore is currently riding a three-game losing streak and has struggled to generate offense, tallying just 23 runs in their past nine games—a modest 2.55 runs per contest. Their September numbers have dipped as well, with the team ranking 25th in weighted runs created plus (wRC+) at 81, despite holding a more respectable 19th position for the entire 2025 season. The White Sox, meanwhile, haven’t fared much better with the bats, ranking 27th in wRC+ (88) for the year and finishing among the league’s weakest offenses.

Taking the mound for Baltimore is right-hander Kyle Bradish, who has been one of the brighter spots for the Orioles this season. Bradish, fresh off a comeback from Tommy John surgery, has posted a 0-1 record with a sparkling 2.65 ERA and a minuscule 0.94 WHIP through his first three starts of 2025. His strikeout-to-walk percentage sits at an impressive 26.2%, and his ability to limit base runners has been a key asset for Baltimore. Bradish’s last outing against the Pittsburgh Pirates was a gem: seven innings pitched, four hits allowed, just one run surrendered, and six strikeouts. He appears poised to challenge a White Sox lineup that has struggled to put up big numbers all season long.

Opposing Bradish will be Chicago’s Sean Burke, who enters the game with a 4-10 record and a 4.35 ERA. Burke’s 1.47 WHIP and 10.5% K-BB% suggest he’s had trouble keeping hitters off the bases and limiting damage, but he’ll look to capitalize on Baltimore’s recent offensive woes. Burke’s ground ball rate is nearly identical to Bradish’s, but his underlying metrics—such as a 5.05 FIP and 4.89 xFIP—indicate that he’s been hit harder than his counterpart. Still, with the White Sox playing at home and hoping to snap out of their own recent funk, Burke will be eager to deliver a quality start.

Betting markets and predictive models have weighed in on this matchup, and the consensus leans slightly in Baltimore’s favor. According to Dimers’ advanced MLB simulations, the Orioles hold a 55% chance of victory, while the White Sox are given a 59% likelihood of covering the +1.5 run line. The total runs line is set at 8, with a 51% probability that the game will stay under—a sentiment echoed by several betting analysts who note the teams’ recent scoring struggles and the environmental factors at play. The odds at publication time favor the Orioles at -142 on the moneyline, while the White Sox are listed at +120, reflecting the tight nature of the contest.

In terms of recent performance, the Orioles have gone 6-4 over their last 10 games, averaging three runs per game with 10 home runs and a staff ERA of 3.79. Gunnar Henderson has been a standout, hitting .271 with 62 RBIs and 16 home runs, and he carries a two-game hitting streak into this matchup. Jackson Holliday, Baltimore’s leader in home runs with 17, is riding a seven-game hitting streak and has been red-hot in his last 10 games, batting .361 with two homers and four RBIs. Ryan Mountcastle and Colton Cowser round out the Orioles’ offensive threats, with Mountcastle posting a .256 average and Cowser adding 14 home runs to his tally.

The White Sox, on the other hand, have split their last 10 games at 5-5, scoring 4.2 runs per game with eight home runs and a 4.40 team ERA. Miguel Vargas (.232, 14 HR), Andrew Benintendi (.241, 19 HR), and Lenyn Sosa (.263, 20 HR) have been key contributors, with Sosa leading the team in both home runs and RBIs (68). Chase Meidroth has also provided a steady bat, hitting .269 with 15 doubles and five home runs. The White Sox will look to capitalize on home field advantage to snap their recent skid and make a statement against the Orioles.

Historically, the Orioles have had the upper hand in this matchup, winning their last three head-to-head games against the White Sox earlier in the 2025 season—3-2 on June 1, 4-2 on May 31, and 2-1 on May 30. The recent history suggests a slight edge for Baltimore, but as always in baseball, anything can happen on any given night.

Environmental conditions at Rate Field are expected to be moderate, with wind direction and temperature unlikely to play a major role in boosting offense. Betting systems that target evening games with muted public interest in the over, recent home team scoring trends, and subtle environmental cues have flagged this contest as a strong candidate for the under. As one analyst put it, "This system in MLB targets evening games where public interest in the over is muted, recent home team scoring has run slightly hot, and subtle environmental signals align with lower-scoring outcomes." The pick: under 8 total runs, with odds of -105.

Fans hoping to catch the action can watch live on CHSN and MASN2, or follow along with box scores and updates on Fox Sports. For those interested in betting, Dimers Pro offers full picks and advice, and Maryland sports fans can take advantage of a special Bet365 bonus offer for the night’s action.

With both teams eager to reverse their fortunes and gain momentum as the season winds down, Monday’s clash at Rate Field promises to be a tightly contested affair. Will Kyle Bradish continue his impressive comeback and stifle the White Sox bats, or will Sean Burke and Chicago’s lineup find a way to break through against a Baltimore squad searching for answers at the plate? One thing’s for sure—the stage is set for a compelling and competitive night of baseball in Chicago.