Kris Jenner, the ever-candid matriarch of the Kardashian-Jenner family, has once again pulled back the curtain on her approach to beauty and wellness. In a revealing conversation on the SHE MD podcast, aired May 5, 2026, Jenner shared her personal experience with the now-infamous weight-loss drug Ozempic—an experience that left her so ill she could barely function, prompting a major shift in her health routine.
"I did not do, like, an Ozempic. I tried it. We tried it once when no one knew what it was, and it made me really sick," Jenner told podcast hosts Dr. Thais Aliabadi and women's advocate Mary Alice Haney, as reported by Entertainment Weekly and People. The 70-year-old businesswoman and reality star recounted how the injectable GLP-1 medication, originally developed for type 2 diabetes, left her nauseous to the point of being unable to work. "I called [Dr. Aliabadi] up one day, and I go, 'I can't work anymore. I can't, I'm so sick. I'm like, nauseous.' And so she goes, 'Okay, okay, let's try something else.'"
Jenner’s struggle with Ozempic came before the drug’s meteoric rise in popularity as a weight-loss solution among celebrities and the public alike. At the time Jenner experimented with it, Ozempic was still largely under the radar, not yet the subject of widespread media coverage or social media speculation. But her reaction was severe enough to send her and her doctor searching for alternatives.
After her adverse reaction, Jenner and Dr. Aliabadi “dialed around and looked at different options,” as Jenner described. The solution they landed on was a regimen of peptide injections, a treatment that quickly became, in Jenner's words, a "game changer." Peptides, short chains of amino acids, have gained traction in recent years for their purported benefits in metabolism, inflammation, and hormone regulation. While some patients report improved energy and pain relief, experts caution that the effects of many peptide injections are not yet fully understood and may carry risks, including stomach discomfort and even pancreatitis, according to the American Medical Association and Jang.
For Jenner, however, peptides—paired with doctor-recommended supplements like fish oil and omega-3s—proved transformative. "I realized that a peptide injection was really great for me," she said on the podcast. "And then I follow it up with supplements." She credited this new routine with giving her more energy, helping her push through long days, and even improving the health of her hair, nails, and skin. "That actually bought me an extra couple hours at night because I get up so early. I tend to want to go and collapse as soon as I have my last email or my last call or see my kids and have dinner and I'm done," Jenner explained, noting that the extra energy was a welcome surprise.
Jenner also emphasized the importance of regular health monitoring, revealing that she gets her blood drawn every three months to keep her hormones balanced—a practice she began after turning 45. "I realized after I was 45 that was so important to your physical female health, just to keep that balanced," she explained, adding that she encourages her son to do the same. "When you look at your thyroid, you look at your hormone health—you look at what your body needs," Jenner said, underscoring her holistic approach to wellness.
Of course, Jenner’s openness about her health journey extends beyond injectables and supplements. Never one to shy away from a little "nipping and tucking," she also admitted to having had a "very well-known facelift a year ago," a procedure that quickly became the subject of tabloid speculation. Addressing rumors that she was dissatisfied with the results, Jenner set the record straight on the Khloé in Wonderland podcast in late April, declaring, "The headline right now is that I hate my facelift, and I'm really mad at—I'm furious at my doctor, Steven Levine, which couldn't be further from the truth. It's a flat-out lie. I love my facelift. I adore my doctor. I'm obsessed with him." She credited Dr. Levine for his work and laughed off the controversy, saying, "That was helpful."
The Kardashian-Jenner family has long been at the center of speculation about beauty treatments and weight-loss methods. Jenner herself first sparked rumors about Ozempic in 2023 after posting vacation photos, leading social media users to dub her an “Ozempic baddie.” Her daughter Khloé Kardashian has also faced scrutiny about using the drug, pushing back against critics by highlighting her commitment to fitness and, later, expressing a nonjudgmental stance: “Who cares? As long as people feel good about themselves.”
Jenner’s candidness on the SHE MD podcast marks the first time she has publicly acknowledged trying Ozempic. Her story stands out in a landscape where celebrities often remain tight-lipped about medical interventions, fueling both curiosity and controversy. As People and Entertainment Weekly note, Jenner’s experience is part of a growing conversation about the risks and rewards of GLP-1 medications, which include Ozempic, Wegovy, and Mounjaro. While some stars, like Serena Williams, have reported positive outcomes with these drugs, others—including Jenner—have found the side effects intolerable or the results unsustainable.
Beyond her own experience, Jenner’s story reflects a broader debate about the use of weight-loss medications. Some experts and advocates warn that the popularity of drugs like Ozempic can overshadow the importance of individualized care and the potential for adverse reactions. As injectable peptides and GLP-1s become more common, the medical community continues to urge caution, emphasizing the need for further research and patient-specific guidance.
For Jenner, the lesson was clear: what works for one person may not work for another. Her willingness to try, fail, and ultimately pivot to a regimen that suits her needs is, in her view, a testament to the importance of self-advocacy in health. “It was really a game changer for me,” she said, noting that the combination of peptide injections, supplements, and regular hormone monitoring has helped her maintain her trademark energy and glow well into her seventies.
As the conversation around celebrity wellness routines continues to evolve, Jenner’s openness offers a rare glimpse behind the curtain. Her story, marked by both missteps and successes, underscores the complexities of navigating modern health trends—and the value of finding what truly works for you.